Updated May 5, 2026 Bottom line Foundayo (orforglipron) and Wegovy pill (oral semaglutide 25 mg) are the first two oral GLP-1 medications approved for chronic weight management. Foundayo is a small molecule and can be taken any time of day with or without food. Wegovy pill is a peptide with
Updated May 5, 2026 Bottom line Compounded semaglutide and tirzepatide are made by compounding pharmacies, not pharmaceutical companies. They were widely available during the FDA shortage period from 2022 to 2024. Both shortages have since been declared over, and in April 2026 the FDA proposed to formally exclude semaglutide, tirzepatide,
Updated May 4, 2026 Bottom line GLP-1 medications mimic a hormone your gut already makes. They slow digestion, reduce appetite, and change how your brain responds to food. Many people lose meaningful weight on them. The medications change appetite. Habits around eating, sleep, and movement still matter for long-term results.